Assay Detail
Functional
CHEMBL5050084
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Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assay
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.98 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5079059 | — | — | 1 | 9.74 |
| CHEMBL5089283 | — | — | 1 | 9.54 |
| CHEMBL5088323 | — | — | 1 | 7.96 |
| CHEMBL5072262 | — | — | 1 | 7.57 |
| CHEMBL5082665 | — | — | 3 | 7.18 |
| CHEMBL5085597 | — | — | 1 | 6.57 |
| CHEMBL5085916 | — | — | 1 | 6.48 |
| CHEMBL5084444 | — | — | 1 | 6.24 |
| CHEMBL5085320 | — | — | 1 | 6.03 |
| CHEMBL5091377 | — | — | 1 | 5.60 |
| CHEMBL5092923 | — | — | 1 | 5.60 |
| CHEMBL5091864 | — | — | 1 | 5.43 |
| CHEMBL5094264 | — | — | 1 | - |
| CHEMBL4650341 | DANAVOREXTON | 2.0 | 1 | - |
| CHEMBL5083834 | — | — | 1 | - |
| CHEMBL5091670 | — | — | 1 | - |
| CHEMBL5074631 | — | — | 1 | - |
| CHEMBL5073349 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5079059 | — | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL5089283 | — | EC50 | = | 0.29 | nM | 9.54 |
| CHEMBL5088323 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5072262 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5082665 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5082665 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5085597 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5085916 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5084444 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5085320 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5091377 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5092923 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5091864 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5083834 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL5094264 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL5082665 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4650341 | DANAVOREXTON | EC50 | = | 5.5 | nM | - |
| CHEMBL5091670 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL5074631 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL5073349 | — | EC50 | > | 30000.0 | nM | - |