Compound Detail
CHEMBL5091377
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CCCS(=O)(=O)N[C@H]1CCCN(C(C)=O)[C@H]1CO[C@H]1CC[C@@H](C(C)C)CC1
Basic Information
| ChEMBL ID | CHEMBL5091377 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PGPHOCNBEFFTNM-YRPNKDGESA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
402.6
MW (Da)
2.93
ALogP
4
HBA
1
HBD
75.7
PSA (Ų)
0.68
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Orexin receptor type 2 CHEMBL4792 | EC50 | 6.0 | 5.9 | 1000.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Orexin receptor type 2 | EC50 | = | 1000.0 | nM | 6.0 | Measurement of Orexin Type 2 Receptor Agonist Activity: Chinese hamster ovary (C... | - |
| Orexin receptor type 2 | EC50 | = | 1000.0 | nM | 6.0 | Measurement of Orexin Type 2 Receptor Agonist Activity: Chinese hamster ovary (C... | - |
| Orexin receptor type 2 | EC50 | = | 1000.0 | nM | 6.0 | Measurement of Orexin Type 2 Receptor Agonist Activity: Chinese hamster ovary (C... | - |
| Orexin receptor type 2 | EC50 | = | 2500.0 | nM | 5.6 | Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux a... | 35295087 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35295087 | 10.1021/acsmedchemlett.1c00626 | Orexin receptor type 2 | 1 |
| 35295087 | 10.1021/acsmedchemlett.1c00626 | Orexin/Hypocretin receptor type 1 | 1 |
Data from ChEMBL 36 via Core Engine