Assay Detail
Functional
CHEMBL5050258
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Antiproliferative activity against human KG-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KG-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design of an Orally Active Anticancer Fluoropyrimidine, Pencitabine, a Hybrid of Capecitabine and Gemcitabine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.89 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.74 |
| CHEMBL5083935 | — | — | 1 | 6.89 |
| CHEMBL1773 | CAPECITABINE | 4.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5083935 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1773 | CAPECITABINE | IC50 | = | 8900.0 | nM | 5.05 |