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Assay Detail

CHEMBL5051771

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human Huh-7 cells after 24 hrs by Cell Titer Glo assay
ChEMBL ↗
234
Total Activities
234
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Huh-7
Confidence 1 — Organism
Curated By Autocuration

Target

Huh-7 (CHEMBL614039) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Gpx4 inhibitors, pharmaceutical compositions thereof, and their use for treating gpx4-mediated diseases
(2021)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 234 6.44 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5083967 — — 1 7.00
CHEMBL5071749 — — 1 7.00
CHEMBL5084577 — — 1 7.00
CHEMBL5081791 — — 1 7.00
CHEMBL5076732 — — 1 7.00
CHEMBL5093432 — — 1 7.00
CHEMBL5094420 — — 1 7.00
CHEMBL5080414 — — 1 7.00
CHEMBL5075601 — — 1 7.00
CHEMBL5081212 — — 1 7.00
CHEMBL5079026 — — 1 7.00
CHEMBL5070936 — — 1 7.00
CHEMBL5091483 — — 1 7.00
CHEMBL5092132 — — 1 7.00
CHEMBL5087402 — — 1 7.00
CHEMBL5076990 — — 1 7.00
CHEMBL5082324 — — 1 7.00
CHEMBL5093845 — — 1 7.00
CHEMBL5074384 — — 1 7.00
CHEMBL5076976 — — 1 7.00
CHEMBL5085158 — — 1 7.00
CHEMBL5079274 — — 1 7.00
CHEMBL5075719 — — 1 7.00
CHEMBL5078887 — — 1 7.00
CHEMBL5076918 — — 1 7.00
CHEMBL5078537 — — 1 7.00
CHEMBL5077427 — — 1 7.00
CHEMBL5081643 — — 1 7.00
CHEMBL5078469 — — 1 7.00
CHEMBL5071054 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5079274 — EC50 = 100.0 nM 7.00
CHEMBL5091483 — EC50 = 100.0 nM 7.00
CHEMBL5092132 — EC50 = 100.0 nM 7.00
CHEMBL5087402 — EC50 = 100.0 nM 7.00
CHEMBL5083967 — EC50 = 100.0 nM 7.00
CHEMBL5082324 — EC50 = 100.0 nM 7.00
CHEMBL5077389 — EC50 = 100.0 nM 7.00
CHEMBL5087434 — EC50 = 100.0 nM 7.00
CHEMBL5080199 — EC50 = 100.0 nM 7.00
CHEMBL5093845 — EC50 = 100.0 nM 7.00
CHEMBL5074384 — EC50 = 100.0 nM 7.00
CHEMBL5076976 — EC50 = 100.0 nM 7.00
CHEMBL5085158 — EC50 = 100.0 nM 7.00
CHEMBL5070936 — EC50 = 100.0 nM 7.00
CHEMBL5075719 — EC50 = 100.0 nM 7.00
CHEMBL5078537 — EC50 = 100.0 nM 7.00
CHEMBL5076918 — EC50 = 100.0 nM 7.00
CHEMBL5077427 — EC50 = 100.0 nM 7.00
CHEMBL5080345 — EC50 = 100.0 nM 7.00
CHEMBL5089531 — EC50 = 100.0 nM 7.00
CHEMBL5078469 — EC50 = 100.0 nM 7.00
CHEMBL5078887 — EC50 = 100.0 nM 7.00
CHEMBL5076990 — EC50 = 100.0 nM 7.00
CHEMBL5084180 — EC50 = 100.0 nM 7.00
CHEMBL5071054 — EC50 = 100.0 nM 7.00
CHEMBL5076732 — EC50 = 100.0 nM 7.00
CHEMBL5081536 — EC50 = 100.0 nM 7.00
CHEMBL5069419 — EC50 = 100.0 nM 7.00
CHEMBL5088673 — EC50 = 100.0 nM 7.00
CHEMBL5086098 — EC50 = 100.0 nM 7.00
CHEMBL5080103 — EC50 = 100.0 nM 7.00
CHEMBL5085489 — EC50 = 100.0 nM 7.00
CHEMBL5088487 — EC50 = 100.0 nM 7.00
CHEMBL5084762 — EC50 = 100.0 nM 7.00
CHEMBL5082557 — EC50 = 100.0 nM 7.00
CHEMBL5071749 — EC50 = 100.0 nM 7.00
CHEMBL5084577 — EC50 = 100.0 nM 7.00
CHEMBL5081791 — EC50 = 100.0 nM 7.00
CHEMBL5074545 — EC50 = 100.0 nM 7.00
CHEMBL5093432 — EC50 = 100.0 nM 7.00
CHEMBL5094420 — EC50 = 100.0 nM 7.00
CHEMBL5090700 — EC50 = 100.0 nM 7.00
CHEMBL5093199 — EC50 = 100.0 nM 7.00
CHEMBL5080414 — EC50 = 100.0 nM 7.00
CHEMBL5075601 — EC50 = 100.0 nM 7.00
CHEMBL5074731 — EC50 = 100.0 nM 7.00
CHEMBL5081212 — EC50 = 100.0 nM 7.00
CHEMBL5071116 — EC50 = 100.0 nM 7.00
CHEMBL5079026 — EC50 = 100.0 nM 7.00
CHEMBL5081115 — EC50 = 100.0 nM 7.00