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Assay Detail

CHEMBL5053007

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Functional
Antiproliferative activity against human MCF7 cells measured by WST-1 assay
ChEMBL ↗
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Foxm1 inhibitor compositions and methods of using the same
(2021)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 49 5.76 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5093236 — — 1 6.22
CHEMBL5076869 — — 1 6.16
CHEMBL5092745 — — 1 6.16
CHEMBL5079369 — — 1 6.16
CHEMBL5089499 — — 1 6.16
CHEMBL5081655 — — 1 6.16
CHEMBL5089867 — — 1 6.16
CHEMBL5075356 — — 1 6.10
CHEMBL5081041 — — 1 6.10
CHEMBL5086654 — — 1 6.10
CHEMBL5082348 — — 1 6.10
CHEMBL5091117 — — 1 6.05
CHEMBL5087943 — — 1 6.05
CHEMBL5094020 — — 1 6.05
CHEMBL5092881 — — 1 6.05
CHEMBL5085183 — — 1 6.00
CHEMBL5076486 — — 1 6.00
CHEMBL5078572 — — 1 5.96
CHEMBL5075226 — — 1 5.96
CHEMBL5069593 — — 1 5.96
CHEMBL5089001 — — 1 5.96
CHEMBL5087967 — — 1 5.92
CHEMBL5094311 — — 1 5.92
CHEMBL5087866 — — 1 5.85
CHEMBL5084668 — — 1 5.82
CHEMBL5093310 — — 1 5.80
CHEMBL5080591 — — 1 5.80
CHEMBL5090466 — — 1 5.80
CHEMBL5078477 — — 1 5.77
CHEMBL5077478 — — 1 5.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5093236 — IC50 = 600.0 nM 6.22
CHEMBL5076869 — IC50 = 700.0 nM 6.16
CHEMBL5089867 — IC50 = 700.0 nM 6.16
CHEMBL5081655 — IC50 = 700.0 nM 6.16
CHEMBL5079369 — IC50 = 700.0 nM 6.16
CHEMBL5092745 — IC50 = 700.0 nM 6.16
CHEMBL5089499 — IC50 = 700.0 nM 6.16
CHEMBL5075356 — IC50 = 800.0 nM 6.10
CHEMBL5081041 — IC50 = 800.0 nM 6.10
CHEMBL5086654 — IC50 = 800.0 nM 6.10
CHEMBL5082348 — IC50 = 800.0 nM 6.10
CHEMBL5092881 — IC50 = 900.0 nM 6.05
CHEMBL5094020 — IC50 = 900.0 nM 6.05
CHEMBL5087943 — IC50 = 900.0 nM 6.05
CHEMBL5091117 — IC50 = 900.0 nM 6.05
CHEMBL5085183 — IC50 = 1000.0 nM 6.00
CHEMBL5076486 — IC50 = 1000.0 nM 6.00
CHEMBL5078572 — IC50 = 1100.0 nM 5.96
CHEMBL5075226 — IC50 = 1100.0 nM 5.96
CHEMBL5069593 — IC50 = 1100.0 nM 5.96
CHEMBL5089001 — IC50 = 1100.0 nM 5.96
CHEMBL5087967 — IC50 = 1200.0 nM 5.92
CHEMBL5094311 — IC50 = 1200.0 nM 5.92
CHEMBL5087866 — IC50 = 1400.0 nM 5.85
CHEMBL5084668 — IC50 = 1500.0 nM 5.82
CHEMBL5080591 — IC50 = 1600.0 nM 5.80
CHEMBL5090466 — IC50 = 1600.0 nM 5.80
CHEMBL5093310 — IC50 = 1600.0 nM 5.80
CHEMBL5078477 — IC50 = 1700.0 nM 5.77
CHEMBL5077478 — IC50 = 1700.0 nM 5.77
CHEMBL5079509 — IC50 = 1800.0 nM 5.75
CHEMBL5089112 — IC50 = 2100.0 nM 5.68
CHEMBL5077012 — IC50 = 2300.0 nM 5.64
CHEMBL5071484 — IC50 = 2400.0 nM 5.62
CHEMBL5090649 — IC50 = 2700.0 nM 5.57
CHEMBL5075586 — IC50 = 3000.0 nM 5.52
CHEMBL5080727 — IC50 = 3000.0 nM 5.52
CHEMBL5075271 — IC50 = 3500.0 nM 5.46
CHEMBL5076704 — IC50 = 3600.0 nM 5.44
CHEMBL5087067 — IC50 = 4000.0 nM 5.40
CHEMBL5075737 — IC50 = 4200.0 nM 5.38
CHEMBL5073130 — IC50 = 4400.0 nM 5.36
CHEMBL5076752 — IC50 = 5500.0 nM 5.26
CHEMBL5092717 — IC50 = 5500.0 nM 5.26
CHEMBL5079996 — IC50 = 6000.0 nM 5.22
CHEMBL5080146 — IC50 = 6000.0 nM 5.22
CHEMBL5085844 — IC50 = 7500.0 nM 5.12
CHEMBL5074652 — IC50 = 9800.0 nM 5.01
CHEMBL5093344 — IC50 = 16000.0 nM 4.80