Assay Detail
Binding
CHEMBL5053181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GMPS
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
GMP synthase [glutamine-hydrolyzing] (CHEMBL5721) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel inhibitors of guanosine monophosphate synthetase as therapeutic agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.62 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094230 | — | — | 1 | 8.21 |
| CHEMBL5093024 | — | — | 1 | 7.64 |
| CHEMBL5080411 | — | — | 1 | 7.01 |
| CHEMBL5079460 | — | — | 1 | - |
| CHEMBL5083238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094230 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5093024 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5080411 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5079460 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5083238 | — | IC50 | > | 1000.0 | nM | - |