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Assay Detail

CHEMBL5053386

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human JIMT-1 cells after 72 hrs by SRB assay
ChEMBL ↗
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type JIMT-1
Confidence 1 — Organism
Curated By Autocuration

Target

JIMT-1 (CHEMBL4296443) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Isoxazole derivatives targeting tacc3 as anticancer agents
(2021)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 53 6.37 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5077643 — — 1 7.89
CHEMBL5092139 — — 1 7.52
CHEMBL5091887 — — 1 7.31
CHEMBL5081205 — — 1 7.28
CHEMBL5086615 — — 1 7.25
CHEMBL5089373 — — 1 6.98
CHEMBL5069496 — — 1 6.95
CHEMBL5093441 — — 1 6.94
CHEMBL5085062 — — 1 6.92
CHEMBL5088900 — — 1 6.92
CHEMBL5094076 — — 1 6.89
CHEMBL5091564 — — 1 6.84
CHEMBL5082878 — — 1 6.80
CHEMBL5076585 — — 1 6.80
CHEMBL5083822 — — 1 6.80
CHEMBL5080791 — — 1 6.69
CHEMBL5075644 — — 1 6.64
CHEMBL5087787 — — 1 6.59
CHEMBL5079625 — — 1 6.43
CHEMBL5078389 — — 1 6.32
CHEMBL5077240 — — 1 6.32
CHEMBL5082855 — — 1 6.27
CHEMBL5091372 — — 1 6.19
CHEMBL5072678 — — 1 6.14
CHEMBL5075227 — — 1 6.10
CHEMBL5083281 — — 1 6.09
CHEMBL5076348 — — 1 6.06
CHEMBL5090307 — — 1 6.00
CHEMBL5080850 — — 1 5.94
CHEMBL5086299 — — 1 5.81

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5077643 — IC50 = 13.0 nM 7.89
CHEMBL5092139 — IC50 = 30.0 nM 7.52
CHEMBL5091887 — IC50 = 49.0 nM 7.31
CHEMBL5081205 — IC50 = 53.0 nM 7.28
CHEMBL5086615 — IC50 = 56.0 nM 7.25
CHEMBL5089373 — IC50 = 105.0 nM 6.98
CHEMBL5069496 — IC50 = 113.0 nM 6.95
CHEMBL5093441 — IC50 = 116.0 nM 6.94
CHEMBL5085062 — IC50 = 120.0 nM 6.92
CHEMBL5088900 — IC50 = 120.0 nM 6.92
CHEMBL5094076 — IC50 = 130.0 nM 6.89
CHEMBL5091564 — IC50 = 145.0 nM 6.84
CHEMBL5083822 — IC50 = 157.0 nM 6.80
CHEMBL5076585 — IC50 = 160.0 nM 6.80
CHEMBL5082878 — IC50 = 160.0 nM 6.80
CHEMBL5080791 — IC50 = 204.0 nM 6.69
CHEMBL5075644 — IC50 = 230.0 nM 6.64
CHEMBL5087787 — IC50 = 259.0 nM 6.59
CHEMBL5079625 — IC50 = 370.0 nM 6.43
CHEMBL5078389 — IC50 = 480.0 nM 6.32
CHEMBL5077240 — IC50 = 480.0 nM 6.32
CHEMBL5082855 — IC50 = 540.0 nM 6.27
CHEMBL5091372 — IC50 = 640.0 nM 6.19
CHEMBL5072678 — IC50 = 730.0 nM 6.14
CHEMBL5075227 — IC50 = 800.0 nM 6.10
CHEMBL5083281 — IC50 = 810.0 nM 6.09
CHEMBL5076348 — IC50 = 870.0 nM 6.06
CHEMBL5090307 — IC50 = 1000.0 nM 6.00
CHEMBL5080850 — IC50 = 1150.0 nM 5.94
CHEMBL5086299 — IC50 = 1560.0 nM 5.81
CHEMBL3186037 — IC50 = 1790.0 nM 5.75
CHEMBL5089424 — IC50 = 2020.0 nM 5.70
CHEMBL5080157 — IC50 = 3090.0 nM 5.51
CHEMBL5091202 — IC50 = 3440.0 nM 5.46
CHEMBL5089189 — IC50 = 3610.0 nM 5.44
CHEMBL5080809 — IC50 = 3970.0 nM 5.40
CHEMBL5085887 — IC50 = 4230.0 nM 5.37
CHEMBL5072148 — IC50 = 7300.0 nM 5.14
CHEMBL5082656 — IC50 = 8270.0 nM 5.08
CHEMBL5089750 — IC50 > 10000.0 nM -
CHEMBL5091264 — IC50 > 10000.0 nM -
CHEMBL5079759 — IC50 > 10000.0 nM -
CHEMBL5090921 — IC50 > 10000.0 nM -
CHEMBL5080967 — IC50 > 10000.0 nM -
CHEMBL5078292 — IC50 > 10000.0 nM -
CHEMBL5093854 — IC50 > 10000.0 nM -
CHEMBL5088023 — IC50 > 10000.0 nM -
CHEMBL5077111 — IC50 > 10000.0 nM -
CHEMBL5093087 — IC50 > 10000.0 nM -
CHEMBL5077696 — IC50 > 10000.0 nM -