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Compound Detail

CHEMBL5091887

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COc1ccc(-c2cc(Nc3ccnc(N4CCCC4)n3)on2)cc1F

Basic Information

ChEMBL ID CHEMBL5091887
Phase Preclinical
Structure Type MOL
InChI Key VCZBNTORTQIQJS-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

355.4
MW (Da)
3.62
ALogP
7
HBA
1
HBD
76.3
PSA (Ų)
0.75
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H18FN5O2
MW 355.37
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -1.98

Activity Summary

IC50 1 meas. best 7.31

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
JIMT-1
CHEMBL4296443
IC50 7.31 7.31 49.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
JIMT-1 IC50 = 49.0 nM 7.31 Antiproliferative activity against human JIMT-1 cells after 72 hrs by SRB assay -

Data from ChEMBL 36 via Core Engine