Assay Detail
Functional
CHEMBL5053572
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4-3 Env-deficient pseudotype virus infected in human U87.CD4.CCR5.CXCR4 cells assessed by reduction in viral infection in early stage measured after 48 hrs by luciferase activity based single-round infection assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | U87.CD4.CCR5.CXCR4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type-1 Capsid Inhibitor Using a Multistep Computational Workflow.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.98 | 7.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5088963 | — | — | 1 | 7.69 |
| CHEMBL5080573 | — | — | 1 | 7.42 |
| CHEMBL5091904 | — | — | 1 | 7.26 |
| CHEMBL5080202 | — | — | 1 | 7.21 |
| CHEMBL1229713 | — | — | 1 | 7.10 |
| CHEMBL5076825 | — | — | 1 | 7.01 |
| CHEMBL5087414 | — | — | 1 | 6.55 |
| CHEMBL5079461 | — | — | 1 | 5.62 |
| CHEMBL5083267 | — | — | 1 | - |
| CHEMBL5081619 | — | — | 1 | - |
| CHEMBL5084038 | — | — | 1 | - |
| CHEMBL5079384 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5088963 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL5080573 | — | IC50 | = | 38.3 | nM | 7.42 |
| CHEMBL5091904 | — | IC50 | = | 55.5 | nM | 7.26 |
| CHEMBL5080202 | — | IC50 | = | 62.1 | nM | 7.21 |
| CHEMBL1229713 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5076825 | — | IC50 | = | 97.2 | nM | 7.01 |
| CHEMBL5087414 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL5079461 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL5083267 | — | IC50 | - | — | - | |
| CHEMBL5081619 | — | IC50 | - | — | - | |
| CHEMBL5084038 | — | IC50 | - | — | - | |
| CHEMBL5079384 | — | IC50 | - | — | - |