Assay Detail
Binding
CHEMBL5053585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TOP2B assessed as reduction in relaxation of supercoiled DNA using kDNA as substrate incubated for 30 min
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.91 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083245 | — | — | 1 | 5.52 |
| CHEMBL1738 | DEXRAZOXANE | 4.0 | 1 | 4.30 |
| CHEMBL5076925 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083245 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1738 | DEXRAZOXANE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5076925 | — | IC50 | = | 505000.0 | nM | - |