Assay Detail
Binding
CHEMBL5053828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length His-tagged human AURB expressed in baculovirus expression system using tetra-LLRASLG peptide as substrate incubated for 180 mins in presence of ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.81 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4864729 | — | — | 1 | 7.89 |
| CHEMBL5079032 | — | — | 1 | 6.29 |
| CHEMBL5089809 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4864729 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5079032 | — | IC50 | = | 511.8 | nM | 6.29 |
| CHEMBL5089809 | — | IC50 | = | 548.4 | nM | 6.26 |