Assay Detail
Binding
CHEMBL5054014
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Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Activity of <i>Mitragyna speciosa</i> ("Kratom") Alkaloids at Serotonin Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.00 | 8.66 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134519 | — | — | 1 | 8.66 |
| CHEMBL4848517 | — | — | 1 | 7.70 |
| CHEMBL4859858 | — | — | 1 | 7.64 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | - |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
| CHEMBL31354 | WAY-100,635 | — | 1 | - |
| CHEMBL297784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134519 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL4848517 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL4859858 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL8412 | IPSAPIRONE | Ki | - | — | - | |
| CHEMBL56 | 8-OH-DPAT | Ki | - | — | - | |
| CHEMBL31354 | WAY-100,635 | Ki | - | — | - | |
| CHEMBL297784 | — | Activity | - | — | - |