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Assay Detail

CHEMBL5054033

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]5-CT from human recombinant 5-HT1A receptor expressed in CHO cells measured after 60 to 90 mins by radioligand completion assay relative to control
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Activity of <i>Mitragyna speciosa</i> ("Kratom") Alkaloids at Serotonin Receptors.
León F, Obeng S, Mottinelli M, Chen Y, King TI, Berthold EC, Kamble SH, Restrepo LF, Patel A, Gamez-Jimenez LR, Lopera-Londoño C, Hiranita T, Sharma A, Hampson AJ, Canal CE, McMahon LR, McCurdy CR.
J Med Chem (2021) 64 : 13510 -13523
PubMed 34467758 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.30 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL8412 IPSAPIRONE 2.0 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL8412 IPSAPIRONE Ki = 49.7 nM 7.30