Assay Detail
Binding
CHEMBL5054551
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluorescent labeled-ligand from ERalpha (unknown origin) by competitive binding assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Searching for an ideal SERM: Mining tamoxifen structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.20 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489 | AFIMOXIFENE | 3.0 | 1 | 8.12 |
| CHEMBL5078348 | — | — | 1 | 8.06 |
| CHEMBL5081507 | — | — | 1 | 7.97 |
| CHEMBL5088475 | — | — | 1 | 7.82 |
| CHEMBL5083906 | — | — | 1 | 7.79 |
| CHEMBL5078187 | — | — | 1 | 7.68 |
| CHEMBL5084400 | — | — | 1 | 7.61 |
| CHEMBL5077058 | — | — | 1 | 7.45 |
| CHEMBL5094047 | — | — | 1 | 7.41 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 7.16 |
| CHEMBL5081355 | — | — | 1 | 7.09 |
| CHEMBL5083006 | — | — | 1 | 6.91 |
| CHEMBL5085178 | — | — | 1 | 6.59 |
| CHEMBL5075395 | — | — | 1 | 6.48 |
| CHEMBL5077738 | — | — | 1 | 6.46 |
| CHEMBL5089862 | — | — | 1 | 6.45 |
| CHEMBL5087904 | — | — | 1 | 6.38 |
| CHEMBL5094779 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489 | AFIMOXIFENE | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5078348 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5081507 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL5088475 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL5083906 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL5078187 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5084400 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL5077058 | — | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL5094047 | — | IC50 | = | 39.1 | nM | 7.41 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5081355 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5083006 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5085178 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL5075395 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL5077738 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL5089862 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL5087904 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL5094779 | — | IC50 | = | 571.0 | nM | 6.24 |