Assay Detail
Binding
CHEMBL5055348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [18F]-FEH from MAO-A in mouse brain homogenate incubated for 60 mins by imaging analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.70 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5082735 | — | — | 1 | 8.11 |
| CHEMBL5084771 | — | — | 1 | 7.29 |
| CHEMBL5088921 | — | — | 1 | - |
| CHEMBL5077904 | — | — | 1 | - |
| CHEMBL5090407 | — | — | 1 | - |
| CHEMBL5081662 | — | — | 1 | - |
| CHEMBL5092563 | — | — | 1 | - |
| CHEMBL5081957 | — | — | 1 | - |
| CHEMBL5091624 | — | — | 1 | - |
| CHEMBL5080178 | — | — | 1 | - |
| CHEMBL5084917 | — | — | 1 | - |
| CHEMBL5081126 | — | — | 1 | - |
| CHEMBL5094590 | — | — | 1 | - |
| CHEMBL5083649 | — | — | 1 | - |
| CHEMBL5091757 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5082735 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL5084771 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5088921 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5077904 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5090407 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5081662 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5092563 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5081957 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5091624 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5080178 | — | IC50 | - | — | - | |
| CHEMBL5084917 | — | IC50 | - | — | - | |
| CHEMBL5081126 | — | IC50 | - | — | - | |
| CHEMBL5094590 | — | IC50 | - | — | - | |
| CHEMBL5083649 | — | IC50 | - | — | - | |
| CHEMBL5091757 | — | IC50 | - | — | - |