Assay Detail
Binding
CHEMBL5055352
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Binding affinity to CM5 immobilized N-terminal His/Sumo tagged Influenza A virus (A/WSN/1933(H1N1)) PB2 CBD (318 to 486 residues) expressed in Escherichia coli by surface plasmon resonance assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/WSN/1933(H1N1)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polymerase basic protein 2 (CHEMBL3317339) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) |
Publication
Identification of novel influenza polymerase PB2 inhibitors using virtual screening approach and molecular dynamics simulation analysis of active compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.25 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | 3.0 | 1 | 7.27 |
| CHEMBL5091340 | — | — | 1 | 6.96 |
| CHEMBL1452338 | — | — | 1 | 6.60 |
| CHEMBL5087029 | — | — | 1 | 6.24 |
| CHEMBL5094914 | — | — | 1 | 5.80 |
| CHEMBL5079585 | — | — | 1 | 5.66 |
| CHEMBL5075807 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318007 | PIMODIVIR | Kd | = | 54.0 | nM | 7.27 |
| CHEMBL5091340 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL1452338 | — | Kd | = | 250.0 | nM | 6.60 |
| CHEMBL5087029 | — | Kd | = | 580.0 | nM | 6.24 |
| CHEMBL5094914 | — | Kd | = | 1600.0 | nM | 5.80 |
| CHEMBL5079585 | — | Kd | = | 2200.0 | nM | 5.66 |
| CHEMBL5075807 | — | Kd | = | 6400.0 | nM | 5.19 |