Assay Detail
Functional
CHEMBL5055756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antinociceptive activity against AITC-induced rat pain model assessed as nocifensive behaviour by measuring unbound concentration
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.33 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094919 | — | — | 1 | 8.21 |
| CHEMBL4870870 | — | — | 1 | 8.10 |
| CHEMBL5093753 | — | — | 1 | 7.31 |
| CHEMBL4849329 | — | — | 1 | 7.28 |
| CHEMBL5091060 | — | — | 1 | 6.66 |
| CHEMBL4863686 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094919 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4870870 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5093753 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4849329 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5091060 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4863686 | — | EC50 | = | 390.0 | nM | 6.41 |