Assay Detail
Binding
CHEMBL5056450
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Sprague-Dawley rat spleen microsome HO-1 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Spleen |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent <i>In Vitro</i> Antiproliferative Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.12 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4166126 | — | — | 1 | 6.57 |
| CHEMBL5090796 | — | — | 1 | 6.05 |
| CHEMBL5081981 | — | — | 1 | 6.05 |
| CHEMBL5089882 | — | — | 1 | 6.02 |
| CHEMBL5082833 | — | — | 1 | 6.02 |
| CHEMBL5074613 | — | — | 1 | 5.92 |
| CHEMBL5079136 | — | — | 1 | 5.68 |
| CHEMBL1188481 | — | — | 1 | 5.40 |
| CHEMBL70611 | AZALANSTAT | 2.0 | 1 | 5.28 |
| CHEMBL5075602 | — | — | 1 | 5.10 |
| CHEMBL5089974 | — | — | 1 | 5.08 |
| CHEMBL5084092 | — | — | 1 | 4.94 |
| CHEMBL5083975 | — | — | 1 | 4.57 |
| CHEMBL4534531 | — | — | 1 | 4.54 |
| CHEMBL5092763 | — | — | 1 | 4.51 |
| CHEMBL5072992 | — | — | 1 | 4.50 |
| CHEMBL5090858 | — | — | 1 | 4.45 |
| CHEMBL5071354 | — | — | 1 | 4.30 |
| CHEMBL563814 | — | — | 1 | 4.24 |
| CHEMBL5093716 | — | — | 1 | 4.19 |
| CHEMBL5091180 | — | — | 1 | 4.02 |
| CHEMBL4571673 | — | — | 1 | - |
| CHEMBL5079290 | — | — | 1 | - |
| CHEMBL5078606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4166126 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5090796 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5081981 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5089882 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5082833 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5074613 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5079136 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1188481 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL70611 | AZALANSTAT | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5075602 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5089974 | — | IC50 | = | 8340.0 | nM | 5.08 |
| CHEMBL5084092 | — | IC50 | = | 11430.0 | nM | 4.94 |
| CHEMBL5083975 | — | IC50 | = | 26840.0 | nM | 4.57 |
| CHEMBL4534531 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL5092763 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL5072992 | — | IC50 | = | 31990.0 | nM | 4.50 |
| CHEMBL5090858 | — | IC50 | = | 35710.0 | nM | 4.45 |
| CHEMBL5071354 | — | IC50 | = | 50630.0 | nM | 4.30 |
| CHEMBL563814 | — | IC50 | = | 57600.0 | nM | 4.24 |
| CHEMBL5093716 | — | IC50 | = | 64800.0 | nM | 4.19 |
| CHEMBL5091180 | — | IC50 | = | 96140.0 | nM | 4.02 |
| CHEMBL4571673 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL5079290 | — | IC50 | = | 224000.0 | nM | - |
| CHEMBL5078606 | — | IC50 | = | 2500000.0 | nM | - |