Assay Detail
Binding
CHEMBL5057134
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of H-PGDS (unknown origin) using fluorescent probe by competition binding assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hematopoietic prostaglandin D synthase (CHEMBL5879) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.80 | 6.85 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5075403 | — | — | 1 | 6.85 |
| CHEMBL5076100 | — | — | 1 | 6.77 |
| CHEMBL4238186 | — | — | 1 | 6.77 |
| CHEMBL5087508 | — | — | 1 | - |
| CHEMBL5085712 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5075403 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5076100 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4238186 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5087508 | — | Inhibition | - | % | - | |
| CHEMBL5085712 | — | Inhibition | - | % | - |