Assay Detail
Binding
CHEMBL5057261
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK3 (unknown origin) incubated for 1 hr in presence of ATP and substrate by FRET based Z'-LYTE assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.56 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4128181 | — | — | 1 | 8.05 |
| CHEMBL5079141 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4128181 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5079141 | — | IC50 | = | 87.2 | nM | 7.06 |