Assay Detail
Binding
CHEMBL5058466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL-2 in CD3/CD28 activated human CD4+ve Th cells preincubated for 15 mins followed by addition of immuno-cult and measured after 24 hrs by HTRF assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CD4+ve Th |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual Inhibition of IL-2-Inducible T-Cell Kinase (ITK) and Tropomyosin Receptor Kinase A (TRKA) as Potential Treatment for Atopic Dermatitis and Other Inflammatory and Autoimmune Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.27 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5087453 | — | — | 1 | 8.00 |
| CHEMBL5090091 | — | — | 1 | 7.89 |
| CHEMBL5088468 | — | — | 1 | 7.47 |
| CHEMBL5084598 | — | — | 1 | 7.41 |
| CHEMBL5074957 | — | — | 1 | 7.33 |
| CHEMBL5079033 | — | — | 1 | 7.09 |
| CHEMBL5082562 | — | — | 1 | 7.04 |
| CHEMBL5086824 | — | — | 1 | 7.02 |
| CHEMBL5080834 | — | — | 1 | 6.95 |
| CHEMBL5083169 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5087453 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5090091 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5088468 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5084598 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5074957 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5079033 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5082562 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL5086824 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL5080834 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5083169 | — | IC50 | = | 304.0 | nM | 6.52 |