Assay Detail
Binding
CHEMBL5059565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive fluorescence polarization binding assay (FKBP5)
2
Total Activities
2
Compounds Tested
1
Activity Types
3
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase FKBP5 (CHEMBL2052031) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Data for DCP probe SAFit2
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 8.22 | 8.22 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Additional information | Additional information | - | — | 3 nM of iFit-FL was used as a tracer. |
| Assay publication | Assay publication | - | — | PMID: 25436518 |
| Target protein length | Target protein length | - | — | FK506-binding domain of FKBP51 (4.5 nM) |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623630 | — | — | 1 | 8.22 |
| CHEMBL5086970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623630 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL5086970 | — | Kd | > | 20000.0 | nM | - |