Assay Detail
Binding
CHEMBL5096372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His6-tagged human Bcl-xL (1 to 196 residues) expressed in Escherichia coli using biotinylated Bim BH3 peptide as substrate incubated for 60 mins by TR-FRET analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Interdiction at a protein-protein interface: MCL-1 inhibitors for oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.16 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446378 | TAPOTOCLAX | 1.0 | 1 | 6.16 |
| CHEMBL4650225 | MURIZATOCLAX | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446378 | TAPOTOCLAX | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL4650225 | MURIZATOCLAX | Ki | > | 5000.0 | nM | - |