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Assay Detail

CHEMBL5096567

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of NUAK1 (unknown origin)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

NUAK family SNF1-like kinase 1 (CHEMBL5784)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development and Therapeutic Potential of NUAKs Inhibitors.
Faisal M, Kim JH, Yoo KH, Roh EJ, Hong SS, Lee SH.
J Med Chem (2021) 64 : 2 -25
PubMed 33356242 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 7.54 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5176650 1 8.85
CHEMBL5199998 1 8.52
CHEMBL4116008 CERDULATINIB 2.0 1 8.40
CHEMBL5196626 1 8.32
CHEMBL577784 BX-795 1 8.30
CHEMBL5204647 1 8.04
CHEMBL5169640 1 7.46
CHEMBL3545311 BRIGATINIB 4.0 1 7.33
CHEMBL535 SUNITINIB 4.0 1 7.32
CHEMBL3544911 PREXASERTIB 2.0 1 7.19
CHEMBL3605057 1 6.64
CHEMBL5182271 1 6.39
CHEMBL5200931 1 5.30
CHEMBL4442620 RONICICLIB 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5176650 IC50 = 1.4 nM 8.85
CHEMBL5199998 IC50 = 3.0 nM 8.52
CHEMBL4116008 CERDULATINIB IC50 = 4.0 nM 8.40
CHEMBL5196626 IC50 = 4.8 nM 8.32
CHEMBL577784 BX-795 IC50 = 5.0 nM 8.30
CHEMBL5204647 IC50 = 9.1 nM 8.04
CHEMBL5169640 IC50 = 34.9 nM 7.46
CHEMBL3545311 BRIGATINIB IC50 = 47.0 nM 7.33
CHEMBL535 SUNITINIB IC50 = 48.0 nM 7.32
CHEMBL3544911 PREXASERTIB IC50 = 64.0 nM 7.19
CHEMBL3605057 IC50 = 230.0 nM 6.64
CHEMBL5182271 IC50 = 411.0 nM 6.39
CHEMBL5200931 IC50 = 5000.0 nM 5.30
CHEMBL4442620 RONICICLIB IC50 < 10.0 nM -