Assay Detail

CHEMBL5096602

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Binding

Binding affinity to NUAK2 (unknown origin) assessed as dissociation constant

ChEMBL ↗

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Target

NUAK family SNF1-like kinase 2 (CHEMBL5698) ↗

Open DB target context

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NUAK family SNF1-like kinase 2 (CHEMBL5698) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NUAK family SNF1-like kinase 2

CHEMBL5698

Anchored from Assay target.

Protein identity NUAK family SNF1-like kinase 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

NUAK family SNF1-like kinase 2 (CHEMBL5698) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Development and Therapeutic Potential of NUAKs Inhibitors.

Faisal M, Kim JH, Yoo KH, Roh EJ, Hong SS, Lee SH.
J Med Chem (2021) 64 : 2 -25
PubMed 33356242 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	8.28	8.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL509032	TAE-684	—	1	8.92
CHEMBL1908394	GSK-461364	1.0	1	7.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL509032	TAE-684	Kd	=	1.2	nM	8.92
CHEMBL1908394	GSK-461364	Kd	=	23.0	nM	7.64