Assay Detail
Binding
CHEMBL5096773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PD-1/PD-L1 interaction (unknown origin) by HTRF binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Recent advance of peptide-based molecules and nonpeptidic small-molecules modulating PD-1/PD-L1 protein-protein interaction or targeting PD-L1 protein degradation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.63 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5182195 | — | — | 1 | 10.40 |
| CHEMBL5196746 | — | — | 1 | 9.32 |
| CHEMBL5180975 | — | — | 1 | 8.83 |
| CHEMBL5176735 | — | — | 1 | 8.65 |
| CHEMBL4089730 | — | — | 1 | 7.75 |
| CHEMBL4099869 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5182195 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5196746 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL5180975 | — | IC50 | = | 1.48 | nM | 8.83 |
| CHEMBL5176735 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL4089730 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4099869 | — | IC50 | = | 146.0 | nM | 6.84 |