Assay Detail

CHEMBL5097003

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Functional

Antagonist activity at resistant Smo D473H mutant (unknown origin) in presence of GDC0449

ChEMBL ↗

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Target

Protein smoothened (CHEMBL5971) ↗

Open DB target context

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Protein smoothened (CHEMBL5971) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Protein smoothened

CHEMBL5971

Anchored from Assay target.

Protein identity Protein smoothened

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Protein smoothened (CHEMBL5971) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Medulloblastoma drugs in development: Current leads, trials and drawbacks.

Wen J, Hadden MK.
Eur J Med Chem (2021) 215 : 113268 -113268
PubMed 33636537 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.40	6.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2142592	TALADEGIB	2.0	1	6.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2142592	TALADEGIB	IC50	=	400.0	nM	6.40