Assay Detail
Binding
CHEMBL5097240
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Inhibition of HDAC3 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histone deacetylase 2: A potential therapeutic target for cancer and neurodegenerative disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.76 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3622533 | FIMEPINOSTAT | 2.0 | 1 | 8.74 |
| CHEMBL2105763 | QUISINOSTAT | 2.0 | 1 | 8.31 |
| CHEMBL4283683 | DOMATINOSTAT | 2.0 | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3622533 | FIMEPINOSTAT | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2105763 | QUISINOSTAT | IC50 | = | 4.86 | nM | 8.31 |
| CHEMBL4283683 | DOMATINOSTAT | IC50 | = | 570.0 | nM | 6.24 |