Assay Detail
Functional
CHEMBL5097371
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of glucose-stimulated insulin secretion in rat INS-1 832/13 cells incubated for 5 mins by ELISA assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | INS1(832/13) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.22 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | 8.22 |
| CHEMBL18901 | EFAPROXIRAL | 3.0 | 1 | 8.22 |
| CHEMBL1201375 | TAZAROTENIC ACID | -1.0 | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL18901 | EFAPROXIRAL | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1201375 | TAZAROTENIC ACID | EC50 | = | 6.0 | nM | 8.22 |