Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL18901

EFAPROXIRAL
🧪 Phase III
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
🧪 Phase III
Cc1cc(C)cc(NC(=O)Cc2ccc(OC(C)(C)C(=O)O)cc2)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL18901
Name EFAPROXIRAL
Phase Phase III
Structure Type MOL
InChI Key BNFRJXLZYUTIII-UHFFFAOYSA-N

Known Names

Efaproxiral RSR-13 RSR13
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
7
Publications
3
Known Names
4
Indications
1
Mechanisms

Molecular Properties

341.4
MW (Da)
3.73
ALogP
3
HBA
2
HBD
75.6
PSA (Ų)
0.84
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Stem ef-
USAN Year 2002

Extended Properties

Molecular Formula C20H23NO4
MW 341.41
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.97

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Hemoglobin HbA negative modulator NEGATIVE MODULATOR Hemoglobin HbA ✓ ✓

Indications

Breast Neoplasms Lung Neoplasms Neoplasms Central Nervous System Neoplasms

ATC Classification

L01XD06
efaproxiral
Level 1: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Level 2: ANTINEOPLASTIC AGENTS

Activity Summary

EC50 1 meas. best 8.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 EC50 8.22 8.22 6.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked EC50 = 6.0 nM 8.22 Induction of glucose-stimulated insulin secretion in rat INS-1 832/13 cells incu... 33771587

Literature References

PubMed DOI Target Context # Activities
11881987 10.1021/jm010358l Hemoglobin HbA 8
1995897 10.1021/jm00106a041 Hemoglobin HbA 6
1995897 10.1021/jm00106a041 NON-PROTEIN TARGET 5
11123981 10.1021/jm000199q Unchecked 3
11123981 10.1021/jm000199q Homo sapiens 3
11123981 10.1021/jm000199q Hemoglobin HbA 2
33771587 10.1016/j.bmcl.2021.127969 Unchecked 1

Data from ChEMBL 36 via Core Engine