Assay Detail
Functional
CHEMBL5097648
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Antiprotozoal activity against Chloroquine-resistant Plasmodium falciparum K1 assessed as parasite growth inhibition
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.18 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5203010 | — | — | 1 | 8.00 |
| CHEMBL5199291 | — | — | 1 | 7.70 |
| CHEMBL2435444 | — | — | 1 | 7.58 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.58 |
| CHEMBL2435416 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5203010 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5199291 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2435444 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL2435416 | — | IC50 | = | 886.0 | nM | 6.05 |