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Assay Detail

CHEMBL5097789

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PTP1B (unknown origin) by SpectraMax 340 microplate reader Analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
Arya GC, Kaur K, Jaitak V.
Eur J Med Chem (2021) 221 : 113511 -113511
PubMed 34000484 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 5.64 6.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5206722 1 6.04
CHEMBL5190487 1 5.76
CHEMBL5185543 1 5.69
CHEMBL1478 LITHOCHOLIC ACID 1 5.57
CHEMBL168 OLEANOLIC_ACID 1 5.53
CHEMBL5179597 1 5.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5206722 IC50 = 910.0 nM 6.04
CHEMBL5190487 IC50 = 1750.0 nM 5.76
CHEMBL5185543 IC50 = 2050.0 nM 5.69
CHEMBL1478 LITHOCHOLIC ACID IC50 = 2710.0 nM 5.57
CHEMBL168 OLEANOLIC_ACID IC50 = 2950.0 nM 5.53
CHEMBL5179597 IC50 = 5370.0 nM 5.27