Assay Detail
Binding
CHEMBL5098050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His-tagged wild-type HIV-1 group M subtype B BH10 reverse transcriptase-associated RNase H activity harboring p66/p51 hetrodimer expressed in Escherichia coli M15 using GTTTTCTTTTCCCCCCTGAC-30 fluorescein/50-CAAAAGAAAAGGGGGGACUG-30 Dabcyl RNA/DNA template-primer as substrate incubated for 1 hr by multilabel counter plate reader analysis
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 4.80 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL550937 | BETA-THUJAPLICINOL | — | 1 | 6.72 |
| CHEMBL5172754 | — | — | 1 | 5.83 |
| CHEMBL5173288 | — | — | 1 | 5.82 |
| CHEMBL5176128 | — | — | 1 | 5.23 |
| CHEMBL5198310 | — | — | 1 | 5.13 |
| CHEMBL5185855 | — | — | 1 | 5.13 |
| CHEMBL5174596 | — | — | 1 | 5.10 |
| CHEMBL5197780 | — | — | 1 | 5.09 |
| CHEMBL5202973 | — | — | 1 | 5.08 |
| CHEMBL5194402 | — | — | 1 | 4.96 |
| CHEMBL5183730 | — | — | 1 | 4.87 |
| CHEMBL5187082 | — | — | 1 | 4.82 |
| CHEMBL5187446 | — | — | 1 | 4.81 |
| CHEMBL5207303 | — | — | 1 | 4.79 |
| CHEMBL5191482 | — | — | 1 | 4.71 |
| CHEMBL5182942 | — | — | 1 | 4.62 |
| CHEMBL5184868 | — | — | 1 | 4.55 |
| CHEMBL5198940 | — | — | 1 | 4.53 |
| CHEMBL5172266 | — | — | 1 | 4.52 |
| CHEMBL5171239 | — | — | 1 | 4.50 |
| CHEMBL5188823 | — | — | 1 | 4.47 |
| CHEMBL5191403 | — | — | 1 | 4.43 |
| CHEMBL5192134 | — | — | 1 | 4.34 |
| CHEMBL5175570 | — | — | 1 | 4.32 |
| CHEMBL5179284 | — | — | 1 | 4.26 |
| CHEMBL3309770 | — | — | 1 | 4.25 |
| CHEMBL5201776 | — | — | 1 | 4.23 |
| CHEMBL5185881 | — | — | 1 | 4.13 |
| CHEMBL5172028 | — | — | 1 | 4.00 |
| CHEMBL5208591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL550937 | BETA-THUJAPLICINOL | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5172754 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL5173288 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL5176128 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5198310 | — | IC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL5185855 | — | IC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL5174596 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5197780 | — | IC50 | = | 8190.0 | nM | 5.09 |
| CHEMBL5202973 | — | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL5194402 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5183730 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL5187082 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL5187446 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL5207303 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL5191482 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL5182942 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5184868 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL5198940 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL5172266 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL5171239 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5188823 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL5191403 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL5192134 | — | IC50 | = | 45500.0 | nM | 4.34 |
| CHEMBL5175570 | — | IC50 | = | 47800.0 | nM | 4.32 |
| CHEMBL5179284 | — | IC50 | = | 55300.0 | nM | 4.26 |
| CHEMBL3309770 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL5201776 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL5185881 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL5172028 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5173434 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5180442 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5171586 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4648347 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5205380 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5188713 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5208821 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5182985 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5183793 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5193857 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5208591 | — | IC50 | > | 100000.0 | nM | - |