Compound Detail
CHEMBL5191482
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Basic Information
| ChEMBL ID | CHEMBL5191482 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HJWJCVFJVHKNPH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
481.5
MW (Da)
6.10
ALogP
5
HBA
0
HBD
57.5
PSA (Ų)
0.26
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.71
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 4.71 | 4.71 | 19600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 19600.0 | nM | 4.71 | Inhibition of recombinant His-tagged wild-type HIV-1 group M subtype B BH10 reve... | 34106711 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34106711 | 10.1021/acs.jmedchem.1c00535 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 34106711 | 10.1021/acs.jmedchem.1c00535 | Human immunodeficiency virus 1 | 1 |
| 34106711 | 10.1021/acs.jmedchem.1c00535 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine