Assay Detail
Functional
CHEMBL5098253
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Antiviral activity against HIV based pseudotyped virus expressing Ebola-GP infected in human HeLa cells assessed as reduction in viral infection preincubated for 1 hrs followed by viral infection and measured after 48hrs by Steady-Glo luciferase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ebolavirus |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potential pharmacological strategies targeting the Niemann-Pick C1 receptor and Ebola virus glycoprotein interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.82 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5172194 | — | — | 1 | 6.43 |
| CHEMBL5197749 | — | — | 1 | 5.69 |
| CHEMBL5171151 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5172194 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5197749 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5171151 | — | IC50 | = | 4690.0 | nM | 5.33 |