Assay Detail
Functional
CHEMBL5098435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RANKL/M-CSF-induced osteoclastogenesis in mouse RAW264.7 cells measured for 4 days by TRAP staining based assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.21 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5186869 | — | — | 1 | 6.07 |
| CHEMBL5184893 | — | — | 1 | 6.07 |
| CHEMBL5178636 | — | — | 1 | 5.98 |
| CHEMBL5173721 | — | — | 1 | 5.73 |
| CHEMBL5185421 | — | — | 1 | 5.44 |
| CHEMBL5208353 | — | — | 1 | 5.16 |
| CHEMBL5204621 | — | — | 1 | 5.06 |
| CHEMBL5188983 | — | — | 1 | 5.06 |
| CHEMBL5192399 | — | — | 1 | 4.89 |
| CHEMBL5182318 | — | — | 1 | 4.83 |
| CHEMBL5182336 | — | — | 1 | 4.76 |
| CHEMBL5206216 | — | — | 1 | 4.68 |
| CHEMBL5174287 | — | — | 1 | 4.67 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5186869 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5184893 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5178636 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL5173721 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL5185421 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL5208353 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5204621 | — | IC50 | = | 8680.0 | nM | 5.06 |
| CHEMBL5188983 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5192399 | — | IC50 | = | 12750.0 | nM | 4.89 |
| CHEMBL5182318 | — | IC50 | = | 14970.0 | nM | 4.83 |
| CHEMBL5182336 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL5206216 | — | IC50 | = | 20750.0 | nM | 4.68 |
| CHEMBL5174287 | — | IC50 | = | 21590.0 | nM | 4.67 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 32380.0 | nM | 4.49 |