Assay Detail
Functional
CHEMBL5098448
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Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-1beta production incubated for 48 hrs by ELISA analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.82 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5173721 | — | — | 1 | 5.63 |
| CHEMBL5185421 | — | — | 1 | 4.79 |
| CHEMBL5188983 | — | — | 1 | 4.68 |
| CHEMBL41286 | DIACEREIN | 3.0 | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5173721 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL5185421 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL5188983 | — | IC50 | = | 20720.0 | nM | 4.68 |
| CHEMBL41286 | DIACEREIN | IC50 | = | 65410.0 | nM | 4.18 |