Assay Detail
Binding
CHEMBL5098546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to DENV2 NS2B/NS3 protease assessed as inhibition constant
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A short survey of dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 4.80 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170076 | — | — | 1 | 5.85 |
| CHEMBL3344303 | — | — | 1 | 5.70 |
| CHEMBL5194503 | — | — | 1 | 5.28 |
| CHEMBL4458555 | — | — | 1 | 4.92 |
| CHEMBL5206550 | — | — | 1 | 4.82 |
| CHEMBL2440339 | — | — | 1 | 4.81 |
| CHEMBL5200710 | — | — | 1 | 4.77 |
| CHEMBL308048 | — | — | 1 | 4.45 |
| CHEMBL1487183 | ALEXIDINE HYDROCHLORIDE | — | 1 | 4.39 |
| CHEMBL403278 | — | — | 1 | 4.36 |
| CHEMBL1908325 | SELAMECTIN | 2.0 | 1 | 4.20 |
| CHEMBL6067487 | IVERMECTIN | 4.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170076 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3344303 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL5194503 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL4458555 | — | Ki | = | 12140.0 | nM | 4.92 |
| CHEMBL5206550 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL2440339 | — | Ki | = | 15600.0 | nM | 4.81 |
| CHEMBL5200710 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL308048 | — | Ki | = | 35700.0 | nM | 4.45 |
| CHEMBL1487183 | ALEXIDINE HYDROCHLORIDE | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL403278 | — | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL1908325 | SELAMECTIN | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL6067487 | IVERMECTIN | Ki | = | 79000.0 | nM | 4.10 |