Assay Detail
Binding
CHEMBL5098733
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Antagonist activity at N-terminal His-tagged cIAP1-BIR3 domain (unknown origin) expressed in Escherichia coli BL21 using AVPIAQKSEK-biotinylated peptide as substrate preincubated for 2 hrs with protein followed by substrate addition measured after 2 hrs by DELFIA assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 2 (CHEMBL5462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.09 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | 2.0 | 1 | 7.80 |
| CHEMBL5174454 | — | — | 1 | 7.03 |
| CHEMBL5195146 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5174454 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5195146 | — | IC50 | = | 370.0 | nM | 6.43 |