Assay Detail
Functional
CHEMBL5099172
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Reversal of 5-FU resistance in human HCT-116 cells overexpressing DPD assessed as reduction in cell viability incubated for 48 hrs in presence of 5-FU by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design, Synthesis, and Biological Evaluation of Novel S1PR2 Antagonists for Reversing 5-FU-Resistance in Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.39 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3401388 | — | — | 1 | 5.67 |
| CHEMBL5181599 | — | — | 1 | 5.58 |
| CHEMBL5206026 | — | — | 1 | 5.54 |
| CHEMBL5193759 | — | — | 1 | 5.53 |
| CHEMBL5172220 | — | — | 1 | 5.50 |
| CHEMBL5206290 | — | — | 1 | 5.40 |
| CHEMBL5208524 | — | — | 1 | 5.19 |
| CHEMBL3759434 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3401388 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL5181599 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL5206026 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL5193759 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL5172220 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL5206290 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL5208524 | — | IC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL3759434 | — | IC50 | = | 18360.0 | nM | 4.74 |