Assay Detail
Functional
CHEMBL5099188
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of 5-FU resistance in human HCT-116 cells overexpressing DPD assessed as reduction in 5-Fluorouracil IC50 at 2 uM incubated for 48 hrs (Rvb = 1836.66 +/- 87.95 %)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design, Synthesis, and Biological Evaluation of Novel S1PR2 Antagonists for Reversing 5-FU-Resistance in Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.25 | 4.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5208524 | — | — | 1 | 4.25 |
| CHEMBL3759434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5208524 | — | IC50 | = | 56410.0 | nM | 4.25 |
| CHEMBL3759434 | — | IC50 | = | 267680.0 | nM | - |