Assay Detail
Functional
CHEMBL5099259
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Agonist activity at human adenosine A1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationship Studies of Novel Adenosine A<sub>1</sub> Receptor-Selective Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 8.58 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174052 | — | — | 1 | 10.00 |
| CHEMBL5195714 | — | — | 1 | 9.91 |
| CHEMBL5187330 | — | — | 1 | 9.88 |
| CHEMBL5172389 | — | — | 1 | 9.85 |
| CHEMBL5203632 | — | — | 1 | 9.62 |
| CHEMBL5171042 | — | — | 1 | 9.53 |
| CHEMBL5174429 | — | — | 1 | 9.28 |
| CHEMBL5201013 | — | — | 1 | 9.28 |
| CHEMBL5205907 | — | — | 1 | 9.21 |
| CHEMBL5197358 | — | — | 1 | 9.03 |
| CHEMBL5186757 | — | — | 1 | 8.98 |
| CHEMBL464859 | NECA | — | 1 | 8.96 |
| CHEMBL5187478 | — | — | 1 | 8.74 |
| CHEMBL5170857 | — | — | 1 | 8.67 |
| CHEMBL5208245 | — | — | 1 | 8.67 |
| CHEMBL5199871 | — | — | 1 | 8.47 |
| CHEMBL3771208 | — | — | 1 | 8.43 |
| CHEMBL5184828 | — | — | 1 | 8.29 |
| CHEMBL5184329 | — | — | 1 | 8.20 |
| CHEMBL5186981 | — | — | 1 | 8.19 |
| CHEMBL5191989 | — | — | 1 | 7.99 |
| CHEMBL5206687 | — | — | 1 | 7.97 |
| CHEMBL5209222 | — | — | 1 | 7.88 |
| CHEMBL5171835 | — | — | 1 | 7.87 |
| CHEMBL5188601 | — | — | 1 | 7.81 |
| CHEMBL5171285 | — | — | 1 | 7.74 |
| CHEMBL5179726 | — | — | 1 | 7.74 |
| CHEMBL5183907 | — | — | 1 | 7.71 |
| CHEMBL5196040 | — | — | 1 | 7.40 |
| CHEMBL5182056 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174052 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5195714 | — | EC50 | = | 0.123 | nM | 9.91 |
| CHEMBL5187330 | — | EC50 | = | 0.1318 | nM | 9.88 |
| CHEMBL5172389 | — | EC50 | = | 0.1413 | nM | 9.85 |
| CHEMBL5203632 | — | EC50 | = | 0.2399 | nM | 9.62 |
| CHEMBL5171042 | — | EC50 | = | 0.2951 | nM | 9.53 |
| CHEMBL5174429 | — | EC50 | = | 0.5248 | nM | 9.28 |
| CHEMBL5201013 | — | EC50 | = | 0.5248 | nM | 9.28 |
| CHEMBL5205907 | — | EC50 | = | 0.6166 | nM | 9.21 |
| CHEMBL5197358 | — | EC50 | = | 0.9333 | nM | 9.03 |
| CHEMBL5186757 | — | EC50 | = | 1.047 | nM | 8.98 |
| CHEMBL464859 | NECA | EC50 | = | 1.096 | nM | 8.96 |
| CHEMBL5187478 | — | EC50 | = | 1.82 | nM | 8.74 |
| CHEMBL5170857 | — | EC50 | = | 2.138 | nM | 8.67 |
| CHEMBL5208245 | — | EC50 | = | 2.138 | nM | 8.67 |
| CHEMBL5199871 | — | EC50 | = | 3.388 | nM | 8.47 |
| CHEMBL3771208 | — | EC50 | = | 3.715 | nM | 8.43 |
| CHEMBL5184828 | — | EC50 | = | 5.129 | nM | 8.29 |
| CHEMBL5184329 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL5186981 | — | EC50 | = | 6.457 | nM | 8.19 |
| CHEMBL5191989 | — | EC50 | = | 10.23 | nM | 7.99 |
| CHEMBL5206687 | — | EC50 | = | 10.72 | nM | 7.97 |
| CHEMBL5209222 | — | EC50 | = | 13.18 | nM | 7.88 |
| CHEMBL5171835 | — | EC50 | = | 13.49 | nM | 7.87 |
| CHEMBL5188601 | — | EC50 | = | 15.49 | nM | 7.81 |
| CHEMBL5171285 | — | EC50 | = | 18.2 | nM | 7.74 |
| CHEMBL5179726 | — | EC50 | = | 18.2 | nM | 7.74 |
| CHEMBL5183907 | — | EC50 | = | 19.5 | nM | 7.71 |
| CHEMBL5196040 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5182056 | — | EC50 | = | 40.74 | nM | 7.39 |
| CHEMBL477 | ADENOSINE | EC50 | = | 69.18 | nM | 7.16 |