Assay Detail
Binding
CHEMBL5099283
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Inhibition of CA200645 binding to wild type NanoLuc-fused human adenosine A1 receptor expressed in HEK293 cells measured at 10 mins by NanoBRET competition binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationship Studies of Novel Adenosine A<sub>1</sub> Receptor-Selective Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.61 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174052 | — | — | 1 | 7.20 |
| CHEMBL5179726 | — | — | 1 | 6.38 |
| CHEMBL3771208 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174052 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL5179726 | — | Ki | = | 416.87 | nM | 6.38 |
| CHEMBL3771208 | — | Ki | = | 575.44 | nM | 6.24 |