Assay Detail
Binding
CHEMBL5099285
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Inhibition of CA200645 binding to NanoLuc-fused human adenosine A1 receptor N70 2.65A mutant expressed in HEK293 cells measured at 10 mins by NanoBRET competition binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationship Studies of Novel Adenosine A<sub>1</sub> Receptor-Selective Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.16 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174052 | — | — | 1 | 7.00 |
| CHEMBL3771208 | — | — | 1 | 6.01 |
| CHEMBL5179726 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174052 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3771208 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL5179726 | — | Ki | = | 3311.31 | nM | 5.48 |