Assay Detail
Binding
CHEMBL5099504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human wild type partial length RIPK3 (M1 to Q307 residues) expressed in bacterial expression system by KINOMEscan TM assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 3 (CHEMBL1795199) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.02 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205822 | — | — | 1 | 7.11 |
| CHEMBL5189681 | — | — | 1 | 6.92 |
| CHEMBL5171828 | — | — | 1 | - |
| CHEMBL5172295 | — | — | 1 | - |
| CHEMBL5185667 | — | — | 1 | - |
| CHEMBL5173571 | — | — | 1 | - |
| CHEMBL5179151 | — | — | 1 | - |
| CHEMBL5189581 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205822 | — | Kd | = | 77.0 | nM | 7.11 |
| CHEMBL5189681 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL5171828 | — | Kd | > | 5000.0 | nM | - |
| CHEMBL5172295 | — | Kd | > | 5000.0 | nM | - |
| CHEMBL5185667 | — | Kd | > | 5000.0 | nM | - |
| CHEMBL5173571 | — | Kd | > | 5000.0 | nM | - |
| CHEMBL5179151 | — | Kd | > | 5000.0 | nM | - |
| CHEMBL5189581 | — | Kd | > | 5000.0 | nM | - |