Assay Detail
Binding
CHEMBL5100012
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Inhibition of CK1alpha (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phenotypic Discovery of Triazolo[1,5-<i>c</i>]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.88 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5186013 | — | — | 1 | 6.66 |
| CHEMBL16687 | CGS-15943 | — | 1 | 6.09 |
| CHEMBL5182545 | — | — | 1 | 5.54 |
| CHEMBL268550 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5186013 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL16687 | CGS-15943 | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5182545 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL268550 | — | IC50 | = | 6180.0 | nM | 5.21 |