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Compound Detail

CHEMBL5186013

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Nc1nc2ccc(Br)cc2c2nc(-c3ccco3)nn12

Basic Information

ChEMBL ID CHEMBL5186013
Phase Preclinical
Structure Type MOL
InChI Key CNPLAHBKWSNADG-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

330.1
MW (Da)
2.88
ALogP
6
HBA
1
HBD
82.2
PSA (Ų)
0.58
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H8BrN5O
MW 330.14
Aromatic Rings 4
Heavy Atoms 20
NP-Likeness -1.82

Activity Summary

IC50 3 meas. best 6.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Casein kinase I isoform delta
CHEMBL2828
IC50 6.92 6.92 120.0 1
Casein kinase I isoform alpha
CHEMBL2793
IC50 6.66 6.66 220.0 1
Casein kinase I isoform epsilon
CHEMBL4937
IC50 6.42 6.42 380.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
36346705 10.1021/acs.jmedchem.2c01199 C2C12 2
36346705 10.1021/acs.jmedchem.2c01199 Casein kinase I isoform delta 1
36346705 10.1021/acs.jmedchem.2c01199 Casein kinase I isoform epsilon 1
36346705 10.1021/acs.jmedchem.2c01199 Casein kinase I isoform alpha 1
36346705 10.1021/acs.jmedchem.2c01199 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
36346705 10.1021/acs.jmedchem.2c01199 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
36346705 10.1021/acs.jmedchem.2c01199 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
36346705 10.1021/acs.jmedchem.2c01199 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
36346705 10.1021/acs.jmedchem.2c01199 Phosphatidylinositol 3-kinase catalytic subunit type 3 1
36346705 10.1021/acs.jmedchem.2c01199 Unchecked 1

Data from ChEMBL 36 via Core Engine