Assay Detail
Functional
CHEMBL5100177
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Cytotoxicity against human HAL-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HAL-01 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.36 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.52 |
| CHEMBL5187433 | — | — | 1 | 6.43 |
| CHEMBL5199849 | — | — | 1 | 5.98 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 5.69 |
| CHEMBL5209024 | — | — | 1 | 5.61 |
| CHEMBL5189808 | — | — | 1 | 5.56 |
| CHEMBL5180418 | — | — | 1 | 5.51 |
| CHEMBL5194945 | — | — | 1 | 5.31 |
| CHEMBL5187865 | — | — | 1 | 5.04 |
| CHEMBL5190554 | — | — | 1 | 5.00 |
| CHEMBL5184839 | — | — | 1 | 4.93 |
| CHEMBL4066043 | — | — | 1 | 4.86 |
| CHEMBL5189667 | — | — | 1 | 4.65 |
| CHEMBL5197066 | — | — | 1 | 4.64 |
| CHEMBL5188109 | — | — | 1 | 4.62 |
| CHEMBL5183285 | — | — | 1 | - |
| CHEMBL5201168 | — | — | 1 | - |
| CHEMBL5204510 | — | — | 1 | - |
| CHEMBL5170634 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL5187433 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL5199849 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5209024 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL5189808 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL5180418 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5194945 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL5187865 | — | IC50 | = | 9120.0 | nM | 5.04 |
| CHEMBL5190554 | — | IC50 | = | 9930.0 | nM | 5.00 |
| CHEMBL5184839 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4066043 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL5189667 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL5197066 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL5188109 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL5183285 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5201168 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5204510 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5170634 | — | IC50 | > | 25000.0 | nM | - |