Assay Detail
Functional
CHEMBL5100178
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Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo luminescent assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.37 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5187433 | — | — | 1 | 6.66 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.66 |
| CHEMBL5199849 | — | — | 1 | 6.31 |
| CHEMBL5209024 | — | — | 1 | 5.84 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 5.81 |
| CHEMBL5187865 | — | — | 1 | 5.70 |
| CHEMBL5180418 | — | — | 1 | 5.61 |
| CHEMBL5194945 | — | — | 1 | 5.32 |
| CHEMBL5184839 | — | — | 1 | 5.17 |
| CHEMBL5190554 | — | — | 1 | 5.11 |
| CHEMBL5189808 | — | — | 1 | 5.04 |
| CHEMBL4066043 | — | — | 1 | 4.95 |
| CHEMBL5183285 | — | — | 1 | 4.91 |
| CHEMBL5170634 | — | — | 1 | 4.91 |
| CHEMBL5197066 | — | — | 1 | 4.89 |
| CHEMBL5188109 | — | — | 1 | 4.87 |
| CHEMBL5189667 | — | — | 1 | 4.80 |
| CHEMBL5201168 | — | — | 1 | 4.74 |
| CHEMBL5204510 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5187433 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5199849 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL5209024 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL5187865 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5180418 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL5194945 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL5184839 | — | IC50 | = | 6790.0 | nM | 5.17 |
| CHEMBL5190554 | — | IC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL5189808 | — | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL4066043 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL5183285 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL5170634 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL5197066 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL5188109 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL5189667 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL5201168 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL5204510 | — | IC50 | = | 18600.0 | nM | 4.73 |