Assay Detail
Functional
CHEMBL5100353
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Antiproliferative activity against mouse BaF3 cells transfected with TEL-AXL assessed as inhibition of cell growth incubated for 72 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.83 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5197792 | — | — | 1 | 8.33 |
| CHEMBL5184891 | — | — | 1 | 8.05 |
| CHEMBL5193925 | — | — | 1 | 7.94 |
| CHEMBL3809489 | BEMCENTINIB | 2.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5197792 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5184891 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5193925 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL3809489 | BEMCENTINIB | IC50 | = | 98.8 | nM | 7.00 |